The cream that actually works. Prescribed for you.
The cream that actually works.
Prescribed for you.
Prescription tretinoin — the only FDA-approved topical proven to reduce wrinkles and smooth skin. Reviewed and prescribed by a licensed provider, personalized for your skin.
Prescription tretinoin — the only FDA-approved topical proven to reduce wrinkles and smooth skin. Reviewed and prescribed by a licensed provider, personalized for your skin.
Prescription tretinoin — the only FDA-approved topical proven to reduce wrinkles and smooth skin. Reviewed and prescribed by a licensed provider, personalized for your skin.
Tretinoin Rx — not OTC retinol
Tretinoin Rx — not OTC retinol
Prescribed by a licensed provider
Prescribed by a licensed provider
Personalized formula for your skin
Personalized formula for your skin
Results visible in 8 weeks
Results visible in 8 weeks
From $35/month · Cancel anytime · Prescription included
From $35/month · Cancel anytime · Prescription included
300K+
Treatments Delivered
8 wks
Avg. Time to See Results
$35
Starting Price / Month
4.9
Average Customer Rating
5 min
To Complete Consultation
300K+
Treatments Delivered
8 wks
Avg. Time to See Results
$35
Starting Price / Month
4.9
Average Customer Rating
5 min
To Complete Consultation
300K+
Treatments Delivered
8 wks
Avg. Time to See Results
$35
Starting Price / Month
4.9
Average Customer Rating
5 min
To Complete Consultation
Renewal Cream
Renewal Cream
Prescription tretinoin for fine lines, wrinkles & uneven texture
Our most popular formula combines tretinoin — the gold-standard prescription retinoid — with vitamin C for a complete anti-aging treatment. Your provider adjusts the formula as your skin improves.
$35/month · 40% off your first order
$35/month · 40% off your first order
Tretinoin cream,
personalized to your skin.
Tretinoin power meets
personalized prescriptions.
Tretinoin power meets personalized
prescriptions.
A real licensed provider reviews your skin assessment and prescribes your Renewal Cream formula — tretinoin at the right strength for you, combined with vitamin C. Your skin changes. Your formula can too.
Prescribed after reviewing your specific skin assessment
Prescribed after reviewing your specific skin assessment
Formula strength adjusted as your skin builds tolerance
Formula strength adjusted as your skin builds tolerance
Compounded fresh in licensed U.S. pharmacies
Compounded fresh in licensed U.S. pharmacies
Unlimited provider check-ins — adjust anytime
Unlimited provider check-ins — adjust anytime
No insurance needed · Transparent $35/month pricing
No insurance needed · Transparent $35/month pricing
+
Tretinoin 0.025%
The only FDA-approved topical proven to reduce wrinkles by stimulating collagen production and accelerating cell turnover.
The only FDA-approved topical proven to reduce wrinkles by stimulating collagen production and accelerating cell turnover.
Vitamin C 5%
Brightens dull skin, fades discoloration, and amplifies tretinoin's collagen-boosting effect for faster, more visible results.
Brightens dull skin, fades discoloration, and amplifies tretinoin's collagen-boosting effect for faster, more visible results.
Ingredients subject to provider consultation and individual eligibility.
Ingredients subject to provider consultation and individual eligibility.
What goes into your formula
What goes into your formula
1
Tretinoin — The Real Thing
Unlike over-the-counter retinol, tretinoin is a prescription-strength retinoic acid that works immediately on skin receptors — no conversion step needed. That's why it's up to 20x more effective than OTC alternatives. It works by accelerating cell turnover (shedding dead skin faster) and stimulating fibroblasts in the dermis to produce new collagen — the protein responsible for firm, plump, youthful skin.Unlike over-the-counter retinol, tretinoin is a prescription-strength retinoic acid that works immediately on skin receptors — no conversion step needed. That's why it's up to 20x more effective than OTC alternatives. It works by accelerating cell turnover (shedding dead skin faster) and stimulating fibroblasts in the dermis to produce new collagen — the protein responsible for firm, plump, youthful skin.
2
Vitamin C — The Amplifier
Vitamin C (ascorbic acid) is one of the most studied topical antioxidants in dermatology. Combined with tretinoin, it neutralizes free radicals, brightens skin tone, and further supports collagen synthesis. The synergy matters: tretinoin breaks down old, damaged collagen while vitamin C signals new collagen production — creating a powerful remodeling effect over time.Vitamin C (ascorbic acid) is one of the most studied topical antioxidants in dermatology. Combined with tretinoin, it neutralizes free radicals, brightens skin tone, and further supports collagen synthesis. The synergy matters: tretinoin breaks down old, damaged collagen while vitamin C signals new collagen production — creating a powerful remodeling effect over time.
1
Tretinoin — The Real Thing
Unlike over-the-counter retinol, tretinoin is a prescription-strength retinoic acid that works immediately on skin receptors — no conversion step needed. That's why it's up to 20x more effective than OTC alternatives. It works by accelerating cell turnover (shedding dead skin faster) and stimulating fibroblasts in the dermis to produce new collagen — the protein responsible for firm, plump, youthful skin.Unlike over-the-counter retinol, tretinoin is a prescription-strength retinoic acid that works immediately on skin receptors — no conversion step needed. That's why it's up to 20x more effective than OTC alternatives. It works by accelerating cell turnover (shedding dead skin faster) and stimulating fibroblasts in the dermis to produce new collagen — the protein responsible for firm, plump, youthful skin.2
Vitamin C — The Amplifier
Vitamin C (ascorbic acid) is one of the most studied topical antioxidants in dermatology. Combined with tretinoin, it neutralizes free radicals, brightens skin tone, and further supports collagen synthesis. The synergy matters: tretinoin breaks down old, damaged collagen while vitamin C signals new collagen production — creating a powerful remodeling effect over time.Vitamin C (ascorbic acid) is one of the most studied topical antioxidants in dermatology. Combined with tretinoin, it neutralizes free radicals, brightens skin tone, and further supports collagen synthesis. The synergy matters: tretinoin breaks down old, damaged collagen while vitamin C signals new collagen production — creating a powerful remodeling effect over time.
1
Tretinoin — The Real Thing
2
Vitamin C — The Amplifier
What to expect week by week
1-2
Adjustment
Adjustment
Skin builds tolerance. Mild dryness or flaking is normal — this is tretinoin working.
3-4
Purging Phase
Purging Phase
Cell turnover accelerates. Some temporary breakouts may occur as skin clears out.
6–8
First Visible Results
First Visible Results
Texture smooths noticeably. Fine lines begin to soften. Skin looks brighter and more even.
3 MO
Significant Improvement
Significant Improvement
Wrinkles visibly reduced. Collagen production is in full effect. Skin firms and glows.
6+ MO
Long-Term Results
Long-Term Results
Sustained collagen remodeling. Skin looks years younger with consistent use.
1-2
Adjustment
Skin builds tolerance. Mild dryness or flaking is normal — this is tretinoin working.
Read More…
Tretinoin vs. retinol — not the same thing
Most people don't realize how large the gap is between OTC retinol and prescription tretinoin. Here's why it matters for your skin.
FDA-approved tretinoin — the only retinoid proven to reduce wrinkles
FDA-approved tretinoin — the only retinoid proven to reduce wrinkles
Works immediately — no conversion needed by your skin
Works immediately — no conversion needed by your skin
Formula customized for your skin type and concern
Formula customized for your skin type and concern
Licensed provider reviews and prescribes after your skin quiz
Licensed provider reviews and prescribes after your skin quiz
Provider adjusts strength as your skin progresses
Provider adjusts strength as your skin progresses
Unlimited check-ins · Compounded in U.S. pharmacies
Unlimited check-ins · Compounded in U.S. pharmacies
![](data:image/svg+xml,<svg display="block" role="presentation" viewBox="0 0 20 20" xmlns="http://www.w3.org/2000/svg"><g d="M 0 18.004 L 0 0.004 L 18 0.004 L 18 18.004 Z M 9 18 C 13.971 18 18 13.971 18 9 C 18 4.029 13.971 0 9 0 C 4.03 0 0 4.029 0 9 C 0 13.971 4.03 18 9 18 Z M 11.701 6.3 L 6.301 11.7 M 6.301 6.3 L 11.701 11.7" fill="transparent" height="18.004394529853016px" id="iJB_nQS3L" transform="translate(1 0.996)" width="18.00020000000335px"><path d="M 0 18 L 0 0 L 18 0 L 18 18 Z" fill="transparent" height="18px" id="BZkvFZXk9" transform="translate(0 0.004)" width="18px"/><path d="M 9 18 C 13.971 18 18 13.971 18 9 C 18 4.029 13.971 0 9 0 C 4.029 0 0 4.029 0 9 C 0 13.971 4.029 18 9 18 Z" fill="rgb(139, 140, 142)" height="17.99999453px" id="XRw4vEgbM" transform="translate(0 0)" width="17.999955859px"/><path d="M 5.4 0 L 0 5.4" fill="transparent" height="5.4px" id="fHX7Asvmk" stroke-dasharray="" stroke-linecap="round" stroke-linejoin="round" stroke-width="1.35" stroke="rgb(255, 255, 255)" transform="translate(6.301 6.3)" width="5.399970000000001px"/><path d="M 0 0 L 5.4 5.4" fill="transparent" height="5.4px" id="xHsr_xlN7" stroke-dasharray="" stroke-linecap="round" stroke-linejoin="round" stroke-width="1.35" stroke="rgb(255, 255, 255)" transform="translate(6.301 6.3)" width="5.399970000000001px"/></g></svg>)
OTC retinol is up to 20× weaker than prescription tretinoin
OTC retinol is up to 20× weaker than prescription tretinoin
Must be converted by your skin — a slow, inefficient process
Must be converted by your skin — a slow, inefficient process
Same formula for every skin type — no personalization
Same formula for every skin type — no personalization
No licensed provider involvement — no prescription
No licensed provider involvement — no prescription
No adjustments if results plateau or irritation occurs
No adjustments if results plateau or irritation occurs
Buy it, try it, toss it, repeat
Buy it, try it, toss it, repeat
FDA-approved tretinoin — the only retinoid proven to reduce wrinkles
Works immediately — no conversion needed by your skin
Formula customized for your skin type and concern
Licensed provider reviews and prescribes after your skin quiz
Provider adjusts strength as your skin progresses
Unlimited check-ins · Compounded in U.S. pharmacies
OTC retinol is up to 20× weaker than prescription tretinoin
Must be converted by your skin — a slow, inefficient process
Same formula for every skin type — no personalization
No licensed provider involvement — no prescription
No adjustments if results plateau or irritation occurs
Buy it, try it, toss it, repeat
STEP 1
Take the 5-Min Skin Quiz
Take the 5-Min Skin Quiz
Take the 5-Min Skin Quiz
Tell us about your skin goals, current routine, and any concerns. Quick, private, and done entirely from your phone or computer.
STEP 2
Your Provider Prescribes
Your Provider Prescribes
Your Provider Prescribes
A licensed dermatology provider reviews your information and prescribes your personalized Renewal Cream formula — tretinoin at the right strength for your skin.
STEP 3
Delivered Every 60 Days
Delivered Every 60 Days
Delivered Every 60 Days
Your Renewal Cream ships discreetly to your door. Ongoing check-ins with your provider keep your formula on track as your skin improves.
Guided by respected dermatologists
Your formula is reviewed by board-certified providers with decades of clinical expertise.
Dr. Shah
Board Certified Dermatologist
Dr. Maxfield
Board Certified Dermatologist
Dr. Tripathi
Double Board Certified Facial Plastic Surgeon
Dr. Stephens
Board Certified Dermatologist
Dr. Shah
Board Certified Dermatologist
Dr. Maxfield
Board Certified Dermatologist
Dr. Tripathi
Double Board Certified Facial Plastic Surgeon
Dr. Stephens
Board Certified Dermatologist
FEATURED IN
FEATURED IN
FEATURED IN
FEATURED IN
FEATURED IN
FEATURED IN
FEATURED IN
FEATURED IN
FEATURED IN
FEATURED IN
Real skin, real progress
Your formula is reviewed by board-certified providers with decades of clinical expertise.
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"I've tried dozens of OTC serums but nothing gave me the results I wanted. After just 3 months on Qure Rx, my skin has improved so much. Best decision I ever made."
Tina A.
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Verified review
"After just 8 weeks, the darkness faded and my skin looked so much more even. My online consultation was easy and I was prescribed something way stronger than anything in stores."
Pamela B.
Verified review
"After 10 weeks on tretinoin, the fine lines around my eyes are noticeably smoother. My skin looks brighter and feels firmer. I wish I'd started this years ago."
Sarah M.
Verified review
"I've tried dozens of OTC serums but nothing gave me the results I wanted. After just 3 months on Qure Rx, my skin has improved so much. Best decision I ever made."
Tina A.
Verified review
"After just 8 weeks, the darkness faded and my skin looked so much more even. My online consultation was easy and I was prescribed something way stronger than anything in stores."
Pamela B.
Verified review
"After 10 weeks on tretinoin, the fine lines around my eyes are noticeably smoother. My skin looks brighter and feels firmer. I wish I'd started this years ago."
Sarah M.
Verified review
Start your tretinoin journey today
Take the free 5-minute skin quiz. Get a prescription Renewal Cream built for your skin — at 40% off your first order.
Have a question?
Have a question?
We have the answer.
We have the answer.
What is tretinoin?
How long does tretinoin take to work?
Why does my skin get worse before it gets better?
How often should I use tretinoin?
Can I use moisturizer with tretinoin?
Should I use sunscreen while using tretinoin?
Can tretinoin help with wrinkles and aging?
Can I use tretinoin with other active ingredients?
How much tretinoin should I apply?
Who should avoid using tretinoin?
© 2026 Qure™ Skincare. All Rights Reserved.
Any information on this website is intended solely for educational purposes only and is in no way intended to substitute for the advice provided by a physician or other healthcare providers. Information on this site are in no way intended to diagnose, treat, cure or prevent any disease.
© 2026 Qure™ Skincare. All Rights Reserved.
Any information on this website is intended solely for educational purposes only and is in no way intended to substitute for the advice provided by a physician or other healthcare providers. Information on this site are in no way intended to diagnose, treat, cure or prevent any disease.
© 2026 Qure™ Skincare. All Rights Reserved.
Any information on this website is intended solely for educational purposes only and is in no way intended to substitute for the advice provided by a physician or other healthcare providers. Information on this site are in no way intended to diagnose, treat, cure or prevent any disease.